Tissue factor as the main activator of the coagulation system during cardiopulmonary bypass

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Cardiopulmonary bypass and the coagulation system

Cardiopulmonary bypass exerts intended and unintended effects on the enzymatic and formed elements of the coagulation and inflammatory systems. Compared with adults, children are at special risk for known, and unknown, differences in their hemostatic systems. Management of these risks will be presented from a surgical perspective, supporting those strategies with a combination of peer-reviewed ...

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15 صفحه اول

The effects of cardiopulmonary bypass on coagulation.

JL Just as a reminder, CPB involves bypassing the heart and the lungs so that the surgeon can operate on them. Most cardiac surgery, including valvular repair and replacement, is performed using CPB. The other option is beating-heart surgery, which can be used for coronary revascularization. In CPB, blood is interfacing with nonendothelial surfaces. This is also called extracorporeal circulatio...

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CONTINUING EDUCATION Coagulation and Platelet Function During Cardiopulmonary Bypass Surgery

Bachmann and coworkers in Chicago have performed a careful study of coagulation parameters after cardiopulmonary bypass surgery .1 In 512 patients, they found a 4% incidence of postoperative bleeding. More than half of these cases were due to surgically correctable causes. About 2% of the population were considered to be bleeding because of an acquired coagulation disorder. One half of these ca...

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ژورنال

عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery

سال: 2002

ISSN: 0022-5223

DOI: 10.1067/mtc.2002.120334